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RECORD NUMBER: 44 OF 50

OLS Field Name OLS Field Data
Main Title Testicular Effects of Dinoseb in Rats.
Author Linder, R. E. ; Scotti, T. M. ; Svendsgaard, D. J. ; McElroy, W. K. ; Curley, A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-81-166;
Stock Number PB84-173160
Additional Subjects Toxicology ; Herbicides ; Ingestion(Biology) ; Rats ; Laboratory animals ; Histology ; Reproductive(System) ; Sperm ; Reprints ; Dinoseb
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB84-173160 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 13p
Abstract
Diets containing the herbicide dinoseb were fed to adult male Sherman rats for 11 weeks. One-half the survivors were killed for terminal studies during the 11th week and the remainder bred to untreated females during posttreatment, and then killed for terminal studies. Interim sacrifices were made in groups fed 0 and 300 ppm. In rats fed 300 ppm, differential classification of spermatozoa from the cauda epididymis indicated 90% of the cells were atypical by 20 days of treatment. By 30 days, bizarre and amorphous forms were observed and epidiymal sperm counts were decreased. Histologic changes in the testes included abnormal spermatozoa and spermatids and multinucleated spermatogenic cells at 20 and 30 days and severe damage to spermatogenic cells by 50 days.