The paper was developed by a task force sponsored by the Interagency Regulatory Liaison Group (IRLG), an alliance of the Consumer Product Safety Commission, the Environmental Protection Agency, the Food and Drug Administration, and the Occupational Safety and Health Administration. Task Force recommendations were subject to interagency review. This paper reflects the results of that review as well as the views of the individual task force members. This paper identifies the major health problems related to toxic substances in the environment and describes the kind of knowledge necessary to combat these problems successfully. It discusses various objectives to which the Government might reasonable aspire and develops criteria for choosing actions to achieve them. It constructs alternative research and training packages and makes cost estimates.