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RECORD NUMBER: 27 OF 50

OLS Field Name OLS Field Data
Main Title NTP Technical Report on Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants Administered in Drinking Water to F344/N Rats and B6C3F1 Mice.
CORP Author National Toxicology Program, Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC.
Publisher Aug 93
Year Published 1993
Report Number NTP-TOXICITY-SER-35 ;NIH/PUB-93-3384;
Stock Number PB94-121498
Additional Subjects Toxicity ; Ground water ; Hazardous materials ; Rats ; Mice ; Exposure ; Dosage ; Concentration(Composition) ; Bone marrow ; Reproductive system ; Salmonella typhimurium ; Escherichia coli ; Body weight ; Genetics ; Mutations ; Photographs ; Tests ; Statistical analysis ; Tables(Data) ; Mutagenicity tests ; Biological effects
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB94-121498 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 02/27/1994
Collation 181p
Abstract
Toxicity studies were performed with a chemically defined mixture of 25 groundwater contaminants, using dose levels considered to have environmental relevance. The mixture contained 19 organic compounds and six metals. The selection of these compounds was based primarily on the frequency of their occurrence in United States Environmental Protection Agency surveys of groundwater contamination in the vicinity of hazardous waste disposal sites. The report focuses primarily on 26-week drinking water toxicity studies with male and female F344/N rats and B6C3F1 mice. The endpoints evaluated included histopathology, clinical pathology, neurobehavior, and reproductive toxicity. Additional studies using this same chemical mixture are briefly reviewed in the report.