||Neuroendocrine Mechanisms Controlling the Onset of Female Puberty.
Urbanski, H. F. ;
Ojeda, S. R. ;
||Oregon Regional Primate Research Center, Beaverton. Div. of Neuroscience.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
||EPA/600/J-88/292 ; OHEA-R-253
Reproductive system ;
Pituitary hormones ;
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The article describes the major neuroendocrine developments that are associated with the normal onset of puberty in the female rats. Although differences exist between rats and humans with regard to development and function of the reproductive system, there are major basic similarities. This makes the rat a valuable laboratory model in which to evaluate the effects of potentially hazardous substances on normal sexual maturation. A systematic experimental approach is presented to show how the study of reproductive development in the female rat can aid understanding of the processes by which these substances could disturb normal puberty in the human female. (Copyright (c) 1988 Pergamon Press plc.)