Record Display for the EPA National Library Catalog

RECORD NUMBER: 23 OF 50

OLS Field Name OLS Field Data
Main Title Male Reproductive Toxicity and Recovery Associated with Acute Ethoxyethanol Exposure in Rats.
Author Oudiz, D. J. ; Zenick, H. ; Niewenhuis, R. J. ; McGinnis, P. M. ;
CORP Author Cincinnati Univ., OH. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/166;
Stock Number PB85-146165
Additional Subjects Toxicology ; Reproductive system ; Exposure ; Rats ; Laboratory animals ; Males ; Bioassay ; Reprints ; Ethoxyethanol
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-146165 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 15p
Abstract
In the present study, effects of 2-ethoxyethanol (EE) on semen parameters in male rats were investigated employing an animal model that allowed assessment of toxicity and recovery in the same animal. Prior to exposure, 7 day old Long-Evans hooded males were placed with ovariectomized, hormonally-primed females on several occasions and their copulatory behaviors were monitored and scored. At 100 days of age, these males were mated with females that were sacrificed 15 minutes postejaculation. The semen sample was recovered from the female reproductive tract and scored for sperm motility, sperm count, and abnormal sperm morphology. Following this pre-exposure baseline assessment, the males were intubated with 0, 936, 1872, or 2808 mg/kg EE for 5 consecutive days. The males were mated weekly for the next 14 weeks. Copulatory behaviors were monitored and ejaculated semen samples analyzed on Weeks 1, 4, 7, 10 and 14.