Abstract |
As a supplemental submission to our earlier TSCA Section 8(e) notifications of July 2, 1996 and December 20, 1996, Dow Corning is submitting the final reports for two range-finding inhalation reproductive toxicity studies in which male.rats were exposed to octamethylcyclotetrasitoxane (OMCTS, 94). In the first study, slight decreases (statistically insignificant) in pup viability and statistically significant reductions in FI pup weights were noted in offspring otmale rats from the high exposure group (700 ppm). A second study of similar design but of greater statistical power failed to detect any indication of adverse effects in pups sired by male similarly exposed to OMCTS. We conclude that OMCTS does not cause adverse effects in the offspring of male rats exposed to OMCTS. |