Main Title |
Receptor classification : the integration of operational, structural, and transductional information / |
Other Authors |
|
Publisher |
New York Academy of Sciences, |
Year Published |
1997 |
OCLC Number |
36512274 |
ISBN |
0897669878 (cloth : alk. paper) 0897669886 (pbk. : alk. paper) 1897669878 (cloth : alk. paper) 18976 |
Subjects |
Neurotransmitter receptors--Congresses ;
Receptors, Cell Surface--classification--congresses ;
Receptors, Drug--classification--congresses
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EKBM |
Q11.N5 v.812 |
|
Research Triangle Park Library/RTP, NC |
07/02/1998 |
|
Collation |
xii, 244 p. : ill. ; 24 cm. |
Notes |
Result of conference ... held in Verona, Italy on Sept. 21-22, 1995. Includes bibliographical references and index. |
Contents Notes |
Pt. 1. Principles and approaches -- The characterization and classi fication of neurotransmitter receptors -- Protein structures in rece ptor classification -- Transduction is a major factor influencing re ceptor characterization -- To what extent can binding studies allow the quantification of affinity and efficacy? -- Pt. 2. Current issue s and challenges -- Criteria for the classificaiton of hormone recep tors with implications for nomenclature: an impossible task? -- Do r ecombinant receptor assays provide affinity and potency estimates? - - How receptor mutagenesis may confirm or confuse receptor nomenclat ure -- A genome-based receptor nomenclature -- Pt. 3. Influence of r ecent theoretical advances -- Do recent operational studies indicate that a single state model is no longer applicable to G-protein-coup led receptors? -- Agonist efficacy and allosteric models of receptor action -- Protean agonists: keys to receptor-active states? -- Is p romiscuity of G-protein interaction an issue in the classification o f receptors? -- Kinetic modesl of ion channels -- Pt. 4. Oral commun ication -- The classification of bioamine receptors: how helpful are molecular phylogenies? -- Neurokinnin receptors: comparison of data from classical pharmacology, binding, and molecular biology -- The alpha and omega of G-protein-coupled receptors: a novel method for c lassification -- Evoluntionary conservation of the 5-HT2beta recepto rs -- General discussion -- Poster presentations. |