Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Receptor classification : the integration of operational, structural, and transductional information /
Other Authors
Author Title of a Work
Trist, D. G.
Publisher New York Academy of Sciences,
Year Published 1997
OCLC Number 36512274
ISBN 0897669878 (cloth : alk. paper) 0897669886 (pbk. : alk. paper) 1897669878 (cloth : alk. paper) 18976
Subjects Neurotransmitter receptors--Congresses ; Receptors, Cell Surface--classification--congresses ; Receptors, Drug--classification--congresses
Library Call Number Additional Info Location Last
EKBM  Q11.N5 v.812 Research Triangle Park Library/RTP, NC 07/02/1998
Collation xii, 244 p. : ill. ; 24 cm.
Result of conference ... held in Verona, Italy on Sept. 21-22, 1995. Includes bibliographical references and index.
Contents Notes
Pt. 1. Principles and approaches -- The characterization and classi fication of neurotransmitter receptors -- Protein structures in rece ptor classification -- Transduction is a major factor influencing re ceptor characterization -- To what extent can binding studies allow the quantification of affinity and efficacy? -- Pt. 2. Current issue s and challenges -- Criteria for the classificaiton of hormone recep tors with implications for nomenclature: an impossible task? -- Do r ecombinant receptor assays provide affinity and potency estimates? - - How receptor mutagenesis may confirm or confuse receptor nomenclat ure -- A genome-based receptor nomenclature -- Pt. 3. Influence of r ecent theoretical advances -- Do recent operational studies indicate that a single state model is no longer applicable to G-protein-coup led receptors? -- Agonist efficacy and allosteric models of receptor action -- Protean agonists: keys to receptor-active states? -- Is p romiscuity of G-protein interaction an issue in the classification o f receptors? -- Kinetic modesl of ion channels -- Pt. 4. Oral commun ication -- The classification of bioamine receptors: how helpful are molecular phylogenies? -- Neurokinnin receptors: comparison of data from classical pharmacology, binding, and molecular biology -- The alpha and omega of G-protein-coupled receptors: a novel method for c lassification -- Evoluntionary conservation of the 5-HT2beta recepto rs -- General discussion -- Poster presentations.