Abstract |
Timed-pregnant CD(reg) (Sprague-Dawley) rats were exposed to Propasol(reg) Solvent P vapor for six hours/day on gestational days (gd) 6 through 15. Twenty-five rats per group were exposed to Propasol(reg) Solvent P at target concentrations of 0, 100, 750, or 1500 ppm. The corresponding mean analytical concentrations were 0, 98.4, 755, and 1524 ppm. Maternal clinical signs were taken daily, and body weights were measured on gd 0, 6, 9, 12, 15, 18 and 21. Maternal food and water consumption were measured throughout gestation, gd 0-21. In addition, prior to exposure and immediately following the last exposure day, the eyes of dams were examined by a veterinary ophthalmologist. At scheduled sacrifice on gd 21, maternal body veight, gravid uterine veight and liver weight were measured. Maternal eyes were fixed in neutral buffered formalin for subsequent histological examination. Ovarian corpora lutea of pregnancy were counted and all uterine implantation sites were identified and recorded: resorptions (early or late), dead fetuses and live fetuses. All live fetuses were examined for external malformations (including cleft palate) and variations. Approximately 50% per litter were examined for visceral malformations and variations (including craniofacial alterations) and approximately 50% per litter (intact fetuses) were examined for skeletal malformations and variations. |