Record Display for the EPA National Library Catalog
RECORD NUMBER: 1031 OF 3839Main Title | Glutamate Neurotoxicity in the Developing Rat Cochlea is Antagonized by Kynurenic Acid and MK-801. | |||||||||||
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Author | Janssen, R. ; | |||||||||||
CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Publisher | c1992 | |||||||||||
Year Published | 1992 | |||||||||||
Report Number | EPA/600/J-92/024; | |||||||||||
Stock Number | PB93-141349 | |||||||||||
Additional Subjects | Toxicity ; Cochlea ; Nervous system ; Glutamates ; Kynurenic acid ; Dizocilpine maleate ; Ganglia ; Hair cells ; Afferent neurons ; Rats ; Newborn animals ; Neurotoxins ; Reprints ; Glutamate antagonists ; Ototoxicity | |||||||||||
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Collation | 8p | |||||||||||
Abstract | Glutamate (Glu) is neurotoxic in the neonatal rat cochlea, producing hearing impairment which is largely due to the death of spiral ganglion cells, whereas the receptor hair cells are spared. Dendritic processes of the spiral ganglion are postsynaptic to the primary afferent synapse of the auditory system. The experiments reported here were designed to test whether this apparent excitotoxicity can be blocked by Glu antagonists. (Copyright (c) 1992 Elsevier Science Publishers B.V.) |