Main Title |
Effects of Neonatal Methylmercury Exposure on Development of Nucleic Acids and Proteins in Rat Brain: Regional Specificity. |
Author |
Slotkin, T. A. ;
Pachman, S. ;
Kavlock, R. J. ;
Bartolome, J. ;
|
CORP Author |
Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA-R-811621; EPA/600/J-85/193; |
Stock Number |
PB86-120334 |
Additional Subjects |
Proteins ;
Nucleic acids ;
Toxicology ;
Brain ;
Exposure ;
Rats ;
Laboratory animals ;
Reprints ;
Mercury/methyl
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-120334 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
5p |
Abstract |
Exposure of neonatal rats to methylmercury (1 or 2.5 mg/kg SC daily) during the preweaning period caused regionally-specific alterations in DNA, RNA and protein content in brain. In midbrain + brainstem, where neuronal replication and differentiation conclude early, reduced DNA content was prominent at either dose and was apparent well before evidence of general body growth impairment; small deficits in protein content and brain region weight were seen. In contrast, cerebral cortex showed an elevation of DNA in the high dose group and a tendency toward supranormal RNA values at either dose. |