Record Display for the EPA National Library Catalog
RECORD NUMBER: 1831 OF 3839Main Title | Letter from Union Carbide C and P Company, Inc. to US EPA Submitting Studies on Selexol with Attachments. (Sanitized). | |||||||||||
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CORP Author | Allied Chemical Corp., Morristown, NJ. ;Union Carbide and Carbon Corp., New York.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
Publisher | 21 Aug 1990 | |||||||||||
Year Published | 1990 | |||||||||||
Report Number | FYI-OTS-0990-0769S; | |||||||||||
Stock Number | OTS-0000769-1 | |||||||||||
Additional Subjects | Toxicology ; Nervous system ; Behavior ; Rats ; Dose-response relationships ; Motor activity ; Laboratory animals ; Physiology ; Saline ; Testing ; Selexol | |||||||||||
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Collation | 146p | |||||||||||
Abstract | Selexol (trademark) was evaluated for neurobehavioral effects in male Fischer 344 rats at oral dose levels of 1, 0.1, and 0.01 mL/kg (single dose) and 0.5, 0.25, and 0.1 mL/kg (doses on each of five consecutive days). Each dose group contained four animals. In addition, for both the single dose and repeated sets of groups, a vehicle control group received 1 mL/kg of physiological saline on an identical schedule. All animals were evaluated for motor and sensory reflexes and (by an automated testing system) for impairment of learning and performance of a simple signaled response (SR) motor function. Signs similar to those seen in earlier Selexol studies were observed in the neuromuscular screen. |