Record Display for the EPA National Library Catalog
RECORD NUMBER: 1865 OF 3839Main Title | Maternal Hepatic and Embryonic Effects of 1,2,4- Trichlorobenzene in the Rat. | |||||||||||
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Author | Kitchin, K. T. ; Ebron, M. T. ; | |||||||||||
CORP Author | Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Year Published | 1983 | |||||||||||
Report Number | EPA-600/J-83-135; | |||||||||||
Stock Number | PB84-144310 | |||||||||||
Additional Subjects | Toxicology ; Liver ; Reproduction(Biology) ; Embryos ; Rats ; Laboratory animals ; Reprints ; Benzene/trichloro | |||||||||||
Holdings |
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Collation | 14p | |||||||||||
Abstract | The possible maternal hepatic and reproductive effects of 1,2,4-trichlorobenzene (TCB) were assessed in rats given 0, 36, 120, 360, and 1200 mg/kg/day of TCB on Days 9-13 of gestation. The animals were sacrificed on Day 14 of pregnancy. Maternal deaths (2/9 rats 6/6 rats) were recorded in the 360 and 1200 mg/kg/day treatment groups and body weights gain was significantly decreased in the 360 mg/kg/day TCB group. Maternal liver weight liver/body weight ratio, and hepatic microsomal protein content were unaffected by TCB treatment. |