Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 16

OLS Field Name OLS Field Data
Main Title Effect of Chloroquin on Hepatic Microsomal Enzyme of the Squirrel Monkey.
Author Cranmer, M. ; Peoples., A. ;
CORP Author Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab.
Year Published 1971
Stock Number PB-277 604
Additional Subjects Drugs ; Antimalarials ; Liver ; Physiological effects ; Ingestion(Biology) ; Ribosomes ; Enzymes ; Monkeys ; Quinolines ; Bioassay ; Laboratory animals ; Reprints ; Quinoline/chloro-(((diethylamino)-methylbutyl)amino) ; Chloroquine
Holdings
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Status
NTIS  PB-277 604 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 1p
Abstract
The present work was done to examine the possible effect on the hepatic microsomal enzymes and P-450 content of squirrel monkeys treated with chloroquin. Chloroquin was found to stimulate the o-demethylation of p-nitroanisole and the oxidative hydrolysis of EPN but not to increase hepatic P-450. A 30-day 10 mg kg/day chloroquin pretreatment to 4 adult male squirrel monkeys blocked the stimulation of P-450 by a 3 day 5 mg/kg administration of p,p'-DDT and decreased the stimulation of hepatic microsomal enzymes by p,p'-DDT.