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RECORD NUMBER: 13 OF 193

OLS Field Name OLS Field Data
Main Title Analyses of Volatile C2 Haloethanes and Haloethenes in Tissues: Sample Preparation and Extraction.
Author Chen, X. M. ; Dallas, C. E. ; Muralidhara, S. ; Srivatsan, V. ; Bruckner, J. V. ;
CORP Author Georgia Univ., Athens. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.;Air Force Office of Scientific Research, Bolling AFB, DC.
Publisher 26 Feb 93
Year Published 1993
Report Number EPA-R-816258 ;AFOSR-910356; EPA/600/J-94/398;
Stock Number PB95-126470
Additional Subjects Chromatographic analysis ; Tissues(Biology) ; Halohydrocarbons ; Extraction ; Rats ; Gas chromatography ; Aliphatic hydrocarbons ; Parmacokinetics ; Concentration(Composition) ; Quantitative analysis ; Reprints ; Volatile organic compounds ; Tissue chemical burden ; C2 haloethanes ; C2 haloethenes
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Status
NTIS  PB95-126470 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/06/1995
Collation 14p
Abstract
Characterization of the pharmacokinetics of volatile organic compounds (VOCs) requires reliable analytical techniques for measuring tissue concentrations. An extraction procedure was developed which minimized loss of the readily volatilizable compounds, so that they could be quantified by headspace gas chromatography. The procedure was evaluated using four C2 halocarbons (i.e., perchloroethylene (PER), 1,1,1-trichloroethane (TRI), 1,2,2,2-tetrachloroethane (TET), and 1,1,2-trichloroethylene (TCE) of varying physicochemical properties. Percent recoveries of each of the four halocarbons ranged from 73%-104% for the seven spiked tissues. The recoveries did not appear to be tissue-dependent, but did vary somewhat with test chemical, with the least volatile, most lipophilic compounds exhibiting the highest recovery.