Record Display for the EPA National Library Catalog
RECORD NUMBER: 9 OF 139
|OLS Field Name||OLS Field Data|
|Main Title||Background document on the development and use of reference doses /|
|Author||ENVIRON Corporation. ; Rubenstein, R. ; Rubenstein, Reva.|
|CORP Author||ENVIRON Corp., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Solid Waste.|
|Publisher||U.S. Environmental Protection Agency, Office of Solid Waste,|
|Report Number||EPA 530-SW-86-048|
|Subjects||Hazardous wastes--Law and legislation--United States. ; Hazardous wastes--Waste disposal--Environmental aspects--United States.|
|Additional Subjects||Solid waste disposal ; Hazardous materials ; Toxicity ; Data collection ; Doses ; Protocols|
|Collation||60, 22 leaves ; 29 cm|
PART I: The Office of Solid Waste (OSW) of EPA proposed certain restrictions on the land disposal of hazardous wastes. To ensure protection of human health, OSW proposed to place limits on the extent of air and water contamination that may result from long-term, law-level releases of hazardous chemicals from land disposal sites. The two principal determinants of these limits are risk-specific doses (RSDs) and reference doses (RFDs). PART II: A discussion of the various considerations influencing the design of protocols for toxicity testing, provided to guide identification of the most cost-effective means to collect toxicity data, is presented in Part II of this report. Specifically, the options available for selecting the species and sex, and species number, number of dose levels, sample size, and extent of animal examination toward the end of identifying the minimally-acceptable protocol for conducting a required toxicity test are examined.
December 20, 1985. NTIS: PB87-107-173.
Part I: Data needs and apportionment -- Part II: Considerations related to the development of protocols for toxicity studies.