Main Title |
Effects on the Fetus of Maternal Benomyl Exposure in the Protein-Deprived Rat. |
Author |
Zeman, F. ;
Hoogenboom, E. ;
Kavlock, R. ;
Semple, J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis. |
Year Published |
1986 |
Report Number |
EPA/600/J-86/099; |
Stock Number |
PB86-211042 |
Additional Subjects |
Toxicology ;
Pregnancy ;
Exposure ;
Rats ;
Proteins ;
Diet ;
Fetuses ;
Laboratory animals ;
Reprints ;
Benomyl
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-211042 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
The separate and combined effects of protein deprivation and benomyl ((methyl 1-butylcarbomoyl)2-benzimidazole carbamate) exposure were studied in the pregnant rat fed a diet containing 24% (control) or 8% (deficient) casein throughout gestation. Within each diet group, subgroups were gavaged at 31.2 mg/kg body weight with benomyl or corn-oil carrier only on d 7-16 or 7-21 of gestation. No effects on the skeleton were seen. Benomyl exposure in the last 2 wk in dams fed the 24% casein diet resulted in a high incidence of fetal brain anomalies. This effect did not occur in those with benomyl exposure during the period of organogenesis only and was reduced in groups fed the protein-deficient diet. Exposure to benomyl in the last 2 wk in the protein-deprived rat resulted in a decrease in the weight of the fetal heart in excess of that attributable to diet alone. Lungs were a smaller portion of body weight in fetuses of benomyl-treated dams in both diet groups. The teratogenic effect on the brain in animals exposed to benomyl in wk 2 and 3 of gestation suggests that screening for teratogenic effects during organogenesis only may be insufficient. |