Record Display for the EPA National Library Catalog

RECORD NUMBER: 8 OF 13

OLS Field Name OLS Field Data
Main Title Influence of Cortisol on Prostaglandin Synthesis by Fetal Membranes, Placenta, and Uterus of Pregnant Rabbits (Journal Version).
Author Fail, P. A. ; Reynolds, R. P. ;
CORP Author North Carolina State Univ. at Raleigh. ;Research Triangle Inst., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/383;
Stock Number PB89-106827
Additional Subjects Fetal membranes ; Hydrocortisone ; Prostaglandins ; Prostaglandin synthase ; Uterus ; Placenta ; Laboratory animals ; Microsomes ; Induced abortion ; Amniotic fluid ; Pregnancy ; Progesterone ; Reprints ;
Holdings
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Status
NTIS  PB89-106827 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 9p
Abstract
Two experiments were designed to assess the effects of cortisol on prostaglandin-forming cyclooxygenase in 4 gestational tissues of rabbits. Cortisol treatment (12 mg/kg body wt/h) was initiated on day 21 of pregnancy and continued for a 24-h period. In cortisol-treated rabbits, plasma progesterone decreased (P<.01) from 7.2 + or - 0.8 ng/ml on day 21 (pretreatment) to 1.6 + or - 0.2 ng/ml on day 23, 48 hrs after the initiation of cortisol treatment. By 62 h, PGF, PGE2, and cortisol concentrations were all significantly higher (P<.05) in the amniotic fluid of treated animals. However, cortisol treatment did not increase prostaglandin-forming cyclooxygenase activity in fetal or maternal tissues at either 48 or 62 h. Therefore, even though increased prostaglandin production may be responsible for the cortisol-induced abortion, increased cyclooxygenase activity in the gestational compartment was not detected.