Record Display for the EPA National Library Catalog

RECORD NUMBER: 927 OF 1030

OLS Field Name OLS Field Data
Main Title Support: Industrial Hygiene Lab Report on Nickel, and Nickel Carbonyl in Ryton Pellets, with Cover Letter dated 07/22/1991. (Sanitized).
CORP Author Phillips Petroleum Co., Idaho Falls, ID.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1991
Report Number 8EHQ-0791-1252S
Stock Number OTS0529784-2
Additional Subjects Toxicology ; Health effects ; Nickel ; Nickel carbonyl ; Case report ; Mammals ; Humans ; Inhalation ; Industrial hygiene ; Environmental fate ; Production and process ; CAS No 7440-02-0 ; CAS No 13463-39-3
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NTIS  OTS0529784-2 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/14/2010
Collation 31p
Abstract
In a range finding rabbit teratology study conducted at oral doses of 0, 150, 300, 450 and 600 mg/kg, reduced food consumption, ataxia, and in more severely affected animals muscle atrophy, convulsions and death were observed. The incidence of these findings increased as a function of dose and appeared earlier (i.e., after fewer doses) in the high dose group. Fetal toxicity in surviving dams has not yet been evaluated. An additional study to be conducted at lower doses is being planned. In a range finding dog study conducted at feeding levels of 0, 500, 1000, 5000, 7500 or 10,000 ppm, severe treatment- related reduction in food consumption occurred at feeding levels of 5000 ppm and were accompanied by substantial reductions in hemoglobin levels, RBC count and hematocrit. The effects on hematologic parameters became apparent by week 3 and the humane sacrifice of some animals was necessary for males at levels 5000 ppm and for females at 10000 ppm. An evaluation of bone marrow from moribund sacrifice animals indicated the reduction of erythroid cell line. A study aimed at defining the no observable effect level (NOEL) is being planned. This compound is a research and development compound being evaluated for pesticidal purposes. These evaluations for pesticidal purposes are being conducted under the supervision of technically qualified personnel, knowledgeable in handling potentially hazardous chemicals.