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RECORD NUMBER: 14 OF 275

OLS Field Name OLS Field Data
Main Title Acute Skin Irritation Study of Hexamethyldisiloxane in Albino Rabbits with Cover Letter dated 04/20/94.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number 8EHQ-86940001784
Stock Number OTS0572296
Additional Subjects Toxicology ; Health effects ; Hexamethyldisiloxane ; Toxicity ; Primary dermal irritation ; Mammals ; Rabbits ; Dermal ; CAS No 107-46-0 ; Toxic substances ; Laboratory animals
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NTIS  OTS0572296 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 15p
Abstract
An acute dermal irritation study was conducted to assess the skin irritation potential of methyl disiloxane in male New Zealand white rabbits. The test material (0.5 ml) was applied uniformly to two intact, shaved test sites on the dorsal side of 12 male rabbits. The test site was then covered with a semiocculsive covering. Adjacent areas of untreated skin served as the control. The test animals were observed for signs of toxicity, mortality, and general activity. The application sites from groups of 4 animals were examined at 1, 2, 4, 8, 16, and 24 hours post-exposure. Skin irritation scores for erythema, edema, and other evidence of irritation were noted for all animals. No skin irritation was observed in any of the animals at any of the time points examined. In addition, no obvious effects on body weight gain, food consumption, survival, or animal behavior were observed. This assessment indicates methyl disiloxane did not produce dermal irritation or other observable signs of toxicity.