Record Display for the EPA National Library Catalog

RECORD NUMBER: 8 OF 154

OLS Field Name OLS Field Data
Main Title Analysis of Multiple Correlated Binary Outcomes: Application to Rodent Teratology Experiments.
Author Lefkopoulou, M. ; Moore, D. ; Ryan., L. ;
CORP Author Harvard School of Public Health, Boston, MA. Dept. of Biostatistics. ;Dana-Farber Cancer Inst., Boston, MA. ;Temple Univ., Philadelphia, PA. Dept. of Statistics.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/395;
Stock Number PB90-245994
Additional Subjects Toxicology ; Rodents ; Statistical analysis ; Mathematical models ; Multivariate analysis ; Acetazolamide ; Reprints ; Teratogens ; Phenytoin ; Animal pregnancy ; Dose-response relationships
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-245994 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/03/1990
Collation 7p
Abstract
In a developmental toxicity study, pregnant animals are exposed to the test substance and their offspring are assessed for defects. Often, multiple observations are made on each fetus, in which case the data are doubly nested. In the article, the approach of Liang and Zeger (1986) and Liang (1986) is adapted to yield an analysis, which appropriately allows for the correlation structure. (Copyright (c) American Statistical Association.)