| Main Title |
Analysis of Multiple Correlated Binary Outcomes: Application to Rodent Teratology Experiments. |
| Author |
Lefkopoulou, M. ;
Moore, D. ;
Ryan., L. ;
|
| CORP Author |
Harvard School of Public Health, Boston, MA. Dept. of Biostatistics. ;Dana-Farber Cancer Inst., Boston, MA. ;Temple Univ., Philadelphia, PA. Dept. of Statistics.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/395; |
| Stock Number |
PB90-245994 |
| Additional Subjects |
Toxicology ;
Rodents ;
Statistical analysis ;
Mathematical models ;
Multivariate analysis ;
Acetazolamide ;
Reprints ;
Teratogens ;
Phenytoin ;
Animal pregnancy ;
Dose-response relationships
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-245994 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
In a developmental toxicity study, pregnant animals are exposed to the test substance and their offspring are assessed for defects. Often, multiple observations are made on each fetus, in which case the data are doubly nested. In the article, the approach of Liang and Zeger (1986) and Liang (1986) is adapted to yield an analysis, which appropriately allows for the correlation structure. (Copyright (c) American Statistical Association.) |
