Record Display for the EPA National Library Catalog

RECORD NUMBER: 43 OF 154

OLS Field Name OLS Field Data
Main Title Effects of Transplacental Exposure to Chlorinated Phenols.
Author Exon, Jerry H. ; Koller, Loren D. ;
CORP Author Idaho Univ., Moscow.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-R-807267; EPA-600/J-81-373;
Stock Number PB83-187914
Additional Subjects Toxicology ; Placenta ; Rats ; Exposure ; Pregnancy ; Bioassay ; Reproduction(Biology) ; Reprints ; Chlorophenols ; Pentachlorophenol
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB83-187914 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 6p
Abstract
Female rats were exposed to 0,5,50 or 500 ppm of 2-Chlorophenol (2CP) or pentachlorophenol (PCP). The study was designed to produce progeny which were exposed to the chlorophenolic compounds both prenatally and postnatally. Percent conception, litter size, birth weight, and number of stillbirths was determined at parturition. Hematologic parameters and body weights of the progeny were recorded at weaning age (3 weeks). Effects on reproduction were observed in both the 2-CP and PCP-exposed groups, as indicated by decreased litter sizes and increased number of stillborn. The data indicate that these chlorinated phenolic compounds may be feto- or embryotoxic at high doses. Effects on hematologic parameters were not observed. Further study involving transplacental and chronic exposures to these chlorophenolic compounds appears warranted.