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RECORD NUMBER: 20 OF 154

OLS Field Name OLS Field Data
Main Title Comparison of Maternal and Fetal Toxic Dose Responses in Mammals (Journal Version).
Author Rogers, J. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1987
Year Published 1987
Report Number EPA/600/J-87/413;
Stock Number PB89-105597
Additional Subjects Toxic substances ; Toxicology ; Fungicides ; Teratology ; Dosage ; Fetus ; Reviews ; Pregnancy ; Laboratory animals ; Toxicity ; Mammals ; Species specificity ; Reprints ; Dinocap ; Maternal toxicity ; Butenoic acid/isooctyl-dinitrophenyl ester ; Risk assessment
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Status
NTIS  PB89-105597 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 12p
Abstract
The role of maternal toxicity in adverse developmental outcome and the importance of maternal toxicity as a factor in developmental risk assessment have received increasing attention in recent literature. The paper reviews these concepts and some of the experimental approaches that have been used to assess their importance. The often non-parallel nature of maternal and fetal toxic dose response curves make specific comparisons of maternal and fetal toxic doses quite difficult. The use of specific ratios of maternal to fetal toxic doses, such as the A/D ratio and the Relative Teratogenic Index is discussed, including some of the difficulties encountered in assigning such ratios, and a compilation of A/D ratios for compounds for which the ratio could be estimated in more than one mammalian species is included. Results of studies on the fungicide dinocap, for which the A/D ratio does not seem to be consistent across species, are briefly reviewed.