Record Display for the EPA National Library Catalog

RECORD NUMBER: 9 OF 15

OLS Field Name OLS Field Data
Main Title Computer-Automated Structure Evaluation of Antileukemic 9-Anilinoacridines.
Author Klopman, G. ; Macina, O. T. ;
CORP Author Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.;Office of Naval Research, Arlington, VA.
Publisher c1987
Year Published 1987
Report Number EPA-R-812264; EPA/600/J-87/488;
Stock Number PB90-111600
Additional Subjects Antineoplastic agents ; Acridines ; Pharmacology ; Tables(Data) ; Deoxyribonucleic acids ; In vitro analysis ; Reprints ; Leukemia L1210 ; 9-Anilinoacridines ; Computer automated structure evaluation(CASE) ; Structure-activity relationship ; Dose-reponse relationships ; Predictive value of tests
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB90-111600 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/1990
Collation 22p
Abstract
The computer-automated structure evaluation (CASE) program has been applied to the evaluation of antileukemic (L1210) and toxic activities of an extensive series of 9-anilinoacridines. Major molecular fragments relevant to the respective biological end-points were automatically generated and incorporated within equations used to estimate the degree of activity. Correlations of these activating/inactivating fragments with the biological activities are discussed. (Copyright (c) The American Society for Pharmacology and Experimental Therapeutics.)