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RECORD NUMBER: 7 OF 15

OLS Field Name OLS Field Data
Main Title Computer Automated Structure Evaluation of the Carcinogenicity of N-Nitrosothiazolidine and N-Nitrosothiazolidine 4-Carboxylic Acid.
Author Rosenkranz, H. S. ; Klopman, G. ;
CORP Author Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA-R-812264; EPA/600/J-88/406;
Stock Number PB90-111584
Additional Subjects Amines ; Nitroso compounds ; Toxicity ; Reprints ; Computer automated structure evaluation(CASE) ; Carcinogenicity tests ; N-Nitrosothiazolidine ; N-Nitrosothiazolidine-4-carboxylic acid ; Predictive value of tests ; Structure-activity relationship
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB90-111584 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/1990
Collation 6p
Abstract
N-Nitrosothiazolidine 4-carboxylic acid (NTCA), a sulphur-containing nitrosamine present in human urine, was predicted to be non-carcinogenic by CASE, the newly developed Computer Automated Structure Evaluating system. On the other hand, N-nitrosothiazolidine (NTHZ), a nitrosamine present in food products, was predicted to be carcinogenic. The putative non-carcinogenic NTCA may be metabolized to NTHZ, a predicted carcinogen. (Copyright (c) 1987 Pergamon Journals Ltd.)