Record Display for the EPA National Library Catalog

RECORD NUMBER: 6 OF 15

OLS Field Name OLS Field Data
Main Title Computer Automated Structure Evaluation of Quinolone Antibacterial Agents.
Author Klopman, G. ; Macina, O. T. ; Levinson, M. E. ; Rosenkranz, H. S. ;
CORP Author Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA-R-812264; EPA/600/J-87/487;
Stock Number PB90-111618
Additional Subjects Pharmacology ; Tables(Data) ; Reprints ; Anti-infective agents ; Quinolones ; DNA gyrase ; Computer automated structure evaluation(CASE) ; Structure-activity relationship ; Predictive value of tests
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-111618 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/1990
Collation 12p
Abstract
The Computer Automated Structure Evaluation (CASE) program was used to study a series of quinolone antibacterial agents for which experimental data pertaining to DNA gyrase inhibition as well as MICs against several strains of gram-positive and gram-negative bacteria are available. The result of the analysis was the automatic generation of molecular fragments relevant to the respective biological endpoints. The potential significance of these major activating-inactivating fragments to the biological activity is discussed. (Copyright (c) 1987 American Society of Microbiology.)