Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Future directions in research on genetic toxicology of complex mixtures. /
Author Lewtas, J.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Publisher US Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1990
Report Number EPA/600/D-90/246
Stock Number PB91-162602
Additional Subjects Toxicology ; Environmental pollutants ; Mutagens ; Health hazards ; Predictive value of tests ; Carcinogenicity tests ; Bioassay ; Risk assessment ; Mutagenicity tests ; DNA damage ; Reprints
Library Call Number Additional Info Location Last
NTIS  PB91-162602 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 11 pages ; 28 cm
The future assessment of complex mixtures of environmental pollutants will increasingly rely on new interdisciplinary strategies including state-of-the-art genetic and molecular methodologies. Integrated multidisciplinary studies will assess human exposure, dosimetry and cancer risk to complex mixtures of pollutants and apportion the exposure and risk to the various pollution sources. Strategies which hold promise for future studies include: (1) biomonitoring environmental levels, fate, transformation and human exposure; (2) characterization of the genotoxic components of complex mixtures using advanced chemical and bioassay methods; (3) source apportionment of human exposure to mutagens; (4) molecular dosimetry of complex mixtures, and (5) mechanistic studies of the effects of complex mixtures induced by both genetic and non-genetic mechanisms. Important advances in understanding the genetic and carcinogenic effects of complex environmental mixtures will increasingly rely on the successful implementation of multidisciplinary integration of environmental, laboratory and human studies using state-of-the-art biological, chemical and molecular methods.
"EPA 600/D-90/246." Microfiche.