Record Display for the EPA National Library Catalog

RECORD NUMBER: 1 OF 15

OLS Field Name OLS Field Data
Main Title Artificial Intelligence Approach to the Study of the Structural Moieties Relevant to Drug-Receptor Interactions in Aldose Reductase Inhibitors.
Author Klopman, G. ; Buyukbingol, E. ;
CORP Author Case Western Reserve Univ., Cleveland, OH. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.;Office of Naval Research, Arlington, VA.
Publisher c1988
Year Published 1988
Report Number EPA-R-812264, N00014-84-K-0090; EPA/600/J-88/409;
Stock Number PB90-108861
Additional Subjects Enzyme inhibitors ; Pharmacology ; Tables(Data) ; Reprints ; Computer automated structure evaluation(CASE) ; Aldose reductase ; Structure-activity relationship ; Predictive value of tests ; Drug receptors
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-108861 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/1990
Collation 13p
Abstract
The computer-automated structure evaluation program has been used to study 482 compounds relevant to the inhibition of the aldose reductase enzyme. Major activating/inactivating fragments were generated automatically. The significance of these molecular descriptors with respect to the activity of the compounds is discussed. (Copyright (c) The American Society of Pharmacology and Experimental Therapeutics.)