Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Hepatic Porphyria Induced by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin in the Mouse.
Author Goldstein, J. A. ; Hickman, P. ; Bergman, H. ; Vos., J. G. ;
CORP Author Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.
Year Published 1973
Stock Number PB-280 843
Additional Subjects Herbicides ; Porphyria ; Pesticides ; Toxicology ; Nitrogen organic compounds ; Chlorine organic compounds ; Mice ; Metabolic diseases ; Liver ; Dosage ; Ingestion(Biology) ; Bioassay ; Lethal dosage ; Tables(Data) ; Laboratory animals ; Experimental data ; Physiological effects ; Contaminants ; Pathology ; Reprints ; Dioxin/tetrachloro-dibenzo ; Synthetases/aminolevulinate ; Porphyrin/carboxy ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-280 843 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
Oral administration of 4 weekly doses of 25 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin resulted in induction of delta-aminolevulinic acid synthetase and hepatic porphyria in mice. There was a 2,000-fold increase in the liver content of 8- and 7-carboxyporphyrins. A single lethal oral dose of 150 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin also resulted in a 4,000-fold increase in uroporphyrins in the liver. Doses of tetrachlorofibenzo-p-dioxin which resulted in porphyria also resulted in microscopic evidence of marked liver damage and a moderate increase in the total iron content of the liver. At this time, 2,3,7,8-tetrachlorodibenzo-p-dioxin, a contaminant of a variety of environmenal chemicals, is the most potent porphyrogenic chemical known.