Main Title |
Effect of Trichloroethylene on the Exploratory and Locomotor Activity of Rats Exposed during Development. |
Author |
Taylor, D. H. ;
Lagory, K. E. ;
Zaccaro, D. J. ;
Pfohl, R. J. ;
Laurie, R. D. ;
|
CORP Author |
Miami Univ., Oxford, OH. Dept. of Zoology.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA-R-809618; EPA/600/D-85/191; |
Stock Number |
PB85-245967 |
Additional Subjects |
Toxicology ;
Rats ;
Laboratory animals ;
Exposure ;
Behavior ;
Ethylene/trichloro ;
Locomotor activity ;
Water pollution effects(Animals)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-245967 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Trichloroethylene (TCE) is a common contaminant of underground water supplies. To examine the effect of TCE on the developing central nervous system, rats were exposed to TCE throughout gestation until 21 days postpartum via their dams' drinking water. TCE concentrations of 312 ppm, 625 ppm and 1250 ppm were tested. Exploratory behavior was higher in 60- and 90-day old male rats which were exposed to any level of TCE. The effect of TCE-exposure on locomotor activity (running wheel) was also examined in 60-day old males (625 and 1250 ppm exposure groups). Locomotor activity was significantly higher in rats exposed to 1250 ppm TCE. These data suggest that TCE has long-term effects on behavior. |