Record Display for the EPA National Library Catalog
RECORD NUMBER: 485 OF 2032
|OLS Field Name||OLS Field Data|
|Main Title||Behavioral Effects of Acute p-Xylene Inhalation in Rats: Autoshaping, Motor Activity, and Reversal Learning.|
|Author||Bushnell, P. J. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.|
|Additional Subjects||Xylenes ; Cognition ; Learning ; Animal behavior ; Rats ; Reaction time ; Exposure ; Dosage ; Reprints ; Air pollution effects(Animals) ; Neurophysiology|
To evaluate the possibility that p-xylene affects cognitive behavior, young adult male Long-Evans hooded rats inhaled p-xylene at concentrations of 0 or 1600 ppm, 4 hr per day for 1 to 5 days, and were evaluated after exposure on two learning tasks and a test of motor activity. Autoshaping was carried out across 5 successive days with p-xylene exposure in the morning followed by testing in the afternoon. The results were interpreted to indicate that p-xylene inhalation at 16 times the TLV induced hyperactivity and facilitated autoshaping by different means, and that the facilitation of autoshaping was not a directed effect on learning per se.