Record Display for the EPA National Library Catalog

RECORD NUMBER: 4179 OF 4735

OLS Field Name OLS Field Data
Main Title Ten- and Ninety-Day Toxicity Studies of 1,2-Dichlorobenzene Administered by Oral Gavage to Sprague-Dawley Rats.
Author Robinson, M. ; Bercz, J. P. ; Ringhand, H. P. ; Condie, L. W. ; Parnell., M. J. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Army Dugway Proving Ground, UT. ;Air Force Aerospace Medical Research Lab., Wright-Patterson AFB, OH.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/178;
Stock Number PB91-233411
Additional Subjects Toxicity ; Health hazards ; Dose-response relationships ; Liver ; Vacuoles ; Necrosis ; Kidney ; Hematology ; Pathology ; Solvents ; Rats ; Body weight ; Organ weight ; Environmental pollutants ; Reprints ; Dichlorobenzenes
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB91-233411 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/26/1991
Collation 32p
Abstract
Subacute (10-day) and subchronic (90-day) toxicity studies of 1,2-dichlorobenzene (DCB) were conducted in male and female Sprague-Dawley rats. 1,2-Dichlorobenzene was administered in corn oil by oral gavage; control animals received corn oil. At time of sacrifice, gross necropsies were performed and selected tissues were weighed and prepared for histological evaluation. Blood was taken for hematology and clinical chemistry determinations. While there were no definitive dose-related histopathological findings in the subacute study, the data did show a tendency toward an increased frequency of hepatocellular cytoplasmic alterations and vacuolization, and single cell necrosis. In the subchronic study, hepatocellular changes associated with treatment included centrolobular degeneration and hypertrophy, and single cell necrosis in the high dose males and females. Correlating effects observed in clinical chemistry and histopathology with other studies, demonstrate that the liver and kidney are the target organs of 1,2-dichlorobenzene toxicity in the rat.