An introduction to particle toxicology: from coal mining to nanotechnology / Paul J.A. Borm and Ken Donaldson -- Mineralogy and structure of pathogenic particles / Tim Jones and Kelly BâeruBâe -- Particle dosimetry: deposition and clearance from the respiratory tract and translocation towards extra-pulmonary sites / Wolfgang G. Kreyling ... [et al.] -- Particulate air pollutants and small airway remodeling / Andrew Churg -- Particle-mediated extracellular oxidative stress in the lung / Frank J. Kelly and Ian S. Mudway. Particles and cellular oxidative and nitrosative stress / Dale W. Porter, Stephen S. Leonard, and Vincent Castranova -- Interaction of particles with membranes / Barbara Rothen-Rutishauser, Samuel Schèurch, and Peter Gehr -- Particle-associated metals and oxidative stress in signaling / James M. Samet and Andrew J. Ghio -- Proinflammatory effects of particles on macrophages and epithelial cells / Vicki Stone ... [et al.]. Cell-signaling pathways elicited by particulates / Jamie E. Levis and Brooke T. Mossman -- Particle-associated organics and proinflammatory signaling / Francelyne Marano, Sonja Boland, and Armelle Baeza-Squiban -- The asbestos model of interstitial pulmonary fibrosis: TNF-[alpha] and TGF-[beta]1 as mediators of asbestos-induced lung fibrogenesis / Deborah E. Sullivan and Arnold R. Brody. Effects of particles on the immune system / M. Ian Gilmour, Tina Stevens, and Rajiv K. Saxena -- Effects of particles on the cardiovascular system / Nicholas L. Mills ... [et al.] -- Susceptibility to particle effects / Steven R. Kleeberger and Reuben Howden -- Genotoxic effects of particles / Roel P.F. Schins and Tom K. Hei -- Approaches to the toxicological testing of particles / Ken Donaldson ... [et al.] -- Models for testing the pulmonary toxicity of particles: lung bioassay screening studies in male rats with a new formulation of TiO2 particulates / David B. Warheit, Kenneth L. Reed, and Christie M. Sayes. Air pollution and human brain pathology: a role for air pollutants in the pathogenesis of Alzheimer's disease / Lilian Calderâon-Garcidueänas and William Reed -- Biologically based lung dosimetry and exposure-dose-response models for poorly soluble inhaled particles / Lang Tran and Eileen Kuempel -- Nanoparticles in medicine / Paul J.A. Borm and Detlef Mèuller-Schulte -- The toxicology of inhaled particles: summing up an emerging conceptual framework / Ken Donaldson, Lang Tran, and Paul J.A. Borm.