Main Title |
The metabolism of naled inhaled by rats / |
Author |
Berteau, Peter E.
|
Other Authors |
|
Publisher |
Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, |
Year Published |
1977 |
Report Number |
EPA-600/1-77-033 |
Stock Number |
PB-271 976 |
OCLC Number |
52255442 |
Subjects |
Pesticides--Absorption and adsorption ;
Herbicides--Absorption and adsorption ;
Insecticides--Absorption and adsorption ;
Pesticides--Health aspects ;
Naled
|
Additional Subjects |
Toxicity ;
Pesticides ;
Insecticides ;
Particle size ;
Aerosols ;
Respiration ;
Metabolism ;
Rats ;
Bioassay ;
Lethal dosage ;
Tables(Data) ;
Deposition ;
Lung ;
Physiology ;
Phosphorus organic compounds ;
Ingestion(Biology) ;
Injections(Medicine) ;
Peritoneum ;
Toxicology ;
Laboratory animals ;
Labeled substances ;
Naled ;
Phosphoric acid((dibromo-dichloro)ethyl-ester)-(dimethyl-ester) ;
DDVP ;
Metabolites
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600-1-77-033 |
c.1 |
Headquarters Library/Washington,DC |
05/27/2014 |
EJED |
EPA 600/1-77/033 |
|
OCSPP Chemical Library/Washington,DC |
07/01/2005 |
EKBD |
EPA-600/1-77-033 |
|
Research Triangle Park Library/RTP, NC |
06/06/2003 |
EKDD |
EPA 600/1-77-033 |
|
CEMM/EPD Library/Athens,GA |
11/03/2014 |
ELBD ARCHIVE |
EPA 600-1-77-033 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
NTIS |
PB-271 976 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
x, 100 p. : ill. ; 28 cm. |
Abstract |
Naled (Dibrom) was prepared with a (14)carbon label in the 1-ethyl position. The labeled compound was administered in appropriate formulation vehicles to female rats by the inhalation, oral or intraperitoneal routes. Treated animals were either placed in metabolism cages and their excreta and expiration of radioactivity monitored during 48 hours, or they were quickly dissected after sacrifice, the lungs and stomach extracted with ether and metabolic breakdown products analyzed for (14)C products by thin layer chromatography. Some animals were also used to determine the deposition and early distribution of inhaled naled. Urinary levels of radioactivity were higher when animals inhaled the compound than when it was administered by the other routes. Levels deposited in the lung were very low and this fact limited the generation of analytical data on the metabolic changes. However, no evidence was provided to indicate that there was a preferential metabolism to the debrominated form of naled (dichlorvos) when the compound was inhaled contrasted to other routes of administration. |
Notes |
"EPA-600/1-77-033." Interagency Agreement No. IAG-D5-0697. Cover title. "June 1977." Includes bibliographical references. |