Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Scientific and technical assessment report on nitrosamines /
CORP Author National Environmental Research Center (Research Triangle Park, N.C.)
Publisher U.S. Environmental Protection Agency, Office of Research and Development,
Year Published 1977
Report Number EPA-600/6-77-001
Stock Number PB-273 055
OCLC Number 03767039
Subjects Nitroso compounds--Environmental aspects.
Additional Subjects Assessments ; Amines ; Nitroso compounds ; Environmental surveys ; Food contamination ; Toxicity ; Public health ; Carcinogens ; Sources ; Concentration(Composition) ; Water pollution ; Air pollution ; Degradation ; Animals ; Microorganisms ; Physical properties ; Chemical properties ; Epidemiology ; Pollution control ; Ecology ; Soil analysis ; Chemical analysis ; Industrial wastes ; Natural resources ; Exhaust emissions ; Plants(Botany) ; Sources ; Particles ; Atmospheric chemistry ; Stationary sources
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  QD305.N8N3 Region 1 Library/Boston,MA 04/29/2016
EHBD  EPA-600/6-77-001 CEMM/ACESD Library/Narragansett,RI 03/23/2007
EJBD ARCHIVE EPA 600-6-77-001 Headquarters Library/Washington,DC 04/16/2010
EJBD  EPA 600-6-77-001 Headquarters Library/Washington,DC 05/12/2006
EKAM  QD305.N8N3 Region 4 Library/Atlanta,GA 06/24/1994
EKCD  QDh EPA-600/6-77-001 CEMM/GEMMD Library/Gulf Breeze,FL 07/25/2018
ESAD  EPA 600-6-77-001 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB-273 055 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation [103] pages in various pagings : illustrations ; 27 cm.
This report is a review and evaluation of the current knowledge of N-nitrosamines (NA) in the environment as related to possible deleterious effects on human health and welfare. Sources, distribution, measurement, and control technology for NA and their precursors are also considered. NA (characterized by the N-N=O group) are formed by the reaction of amines with nitrous acid. Nearly 70% of all N-nitroso compounds studied have been found to be carcinogenic, with a wide range in potency, in all species of laboratory animals tested via all routes of administration. The experimentally produced carcinogenesis appears to be caused by metabolites rather than by NA themselves. Epidemiological studies to date do not show a direct relationship between exposure to NA and cancer in man. Ambient air concentrations of NA of up to 36 microgram/cu m have been found near an emission source; and of up to 0.2 microgram/cu m in major population centers. The relative contributions of natural and man-made sources are indeterminable at present. Average dietary intake of NA is not likely to exceed a few microgram/day. Intake of NA in municipal drinking water would probably be much less than 1 microgram/day. NA in cigarettes range from 0 to 180 ng/cigarette.
Includes bibliographical references.