Record Display for the EPA National Library Catalog
RECORD NUMBER: 173 OF 249
|OLS Field Name||OLS Field Data|
|Main Title||NTP Technical Report on Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants Administered in Drinking Water to F344/N Rats and B6C3F1 Mice.|
|CORP Author||National Toxicology Program, Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC.|
|Report Number||NTP-TOXICITY-SER-35 ;NIH/PUB-93-3384;|
|Additional Subjects||Toxicity ; Ground water ; Hazardous materials ; Rats ; Mice ; Exposure ; Dosage ; Concentration(Composition) ; Bone marrow ; Reproductive system ; Salmonella typhimurium ; Escherichia coli ; Body weight ; Genetics ; Mutations ; Photographs ; Tests ; Statistical analysis ; Tables(Data) ; Mutagenicity tests ; Biological effects|
Toxicity studies were performed with a chemically defined mixture of 25 groundwater contaminants, using dose levels considered to have environmental relevance. The mixture contained 19 organic compounds and six metals. The selection of these compounds was based primarily on the frequency of their occurrence in United States Environmental Protection Agency surveys of groundwater contamination in the vicinity of hazardous waste disposal sites. The report focuses primarily on 26-week drinking water toxicity studies with male and female F344/N rats and B6C3F1 mice. The endpoints evaluated included histopathology, clinical pathology, neurobehavior, and reproductive toxicity. Additional studies using this same chemical mixture are briefly reviewed in the report.