Record Display for the EPA National Library Catalog

RECORD NUMBER: 2 OF 6

OLS Field Name OLS Field Data
Main Title Effect of pesticide interactions upon the reproductive system /
Author Thomas, John ; Thomas, John A.
Other Authors
Author Title of a Work
Thomas, John A.
Baron, Ronald L.
CORP Author West Virginia Univ. Medical Center, Morgantown. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1978
Report Number EPA/600/1-78/044; EPA-R-803578
Stock Number PB-285 203
Subjects Pesticides--Toxicology. ; Reproductive toxicology.
Additional Subjects Pesticides ; Dieldrin ; Toxicology ; Tables(Data) ; Insecticides ; In vitro analysis ; Rats ; Mice ; Laboratory animals ; Experimental data ; Testosterone ; Sex hormones ; Metabolism ; Prostate gland ; Liver ; Ingestion(Biology) ; Physiological effects ; Sensitivity ; Reproductive system ; Interactions ; Biological effects ; Parathion ; Phosphorothioic acid/0-0-(dimethyl-ester)-0-(nitrophenyl-ester) ; Toxic substances
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=2000ZPBQ.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB-285 203 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation ix, 39 pages : illustrations ; 28 cm.
Abstract
The metabolism of 1,2-3H-testosterone in vitro was studied in prostate glands and livers of rats and mice treated with different pesticides including dieldrin and parathion. The metabolism of 1,2-3H-testosterone (T-3H) in vitro by mouse anterior prostate glands or hepatic microsomes has been studied after the oral administration of dieldrin (2.5 mg/kg daily x 5 or 10) and/or parathion (1.3,2.6, or 5.2 mg/kg daily x 5 or 10). T-3H metabolism in the prostate was unaffected by the various treatment regimens. Dieldrin (10 days) caused some reduction in the microsomal production of androstenedione-3H or dihydrotestosterone-3H. Only treatment regimes with dieldrin stimulated hepatic testosterone hydroxylases; parathion alone had no effect. This study revealed that dieldrin and parathion can interact and produce biological effects different from those caused by either pesticide alone.
Notes
Project Officer: Ronald L. Baron. Department of Pharmacology, West Virginia University Medical Center "June 1978." "EPA-600/1-78-044." PB 285 203--NTIS. "Publication resulting from this EPA Grant" (p.36-37). Includes bibliographical references (pages 31-35). Microfiche.