||Effect of pesticide interactions upon the reproductive system /
Thomas, John ;
Thomas, John A.
||West Virginia Univ. Medical Center, Morgantown. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, N.C.
|| U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
In vitro analysis ;
Laboratory animals ;
Experimental data ;
Sex hormones ;
Prostate gland ;
Physiological effects ;
Reproductive system ;
Biological effects ;
Phosphorothioic acid/0-0-(dimethyl-ester)-0-(nitrophenyl-ester) ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||ix, 39 pages : illustrations ; 28 cm.
The metabolism of 1,2-3H-testosterone in vitro was studied in prostate glands and livers of rats and mice treated with different pesticides including dieldrin and parathion. The metabolism of 1,2-3H-testosterone (T-3H) in vitro by mouse anterior prostate glands or hepatic microsomes has been studied after the oral administration of dieldrin (2.5 mg/kg daily x 5 or 10) and/or parathion (1.3,2.6, or 5.2 mg/kg daily x 5 or 10). T-3H metabolism in the prostate was unaffected by the various treatment regimens. Dieldrin (10 days) caused some reduction in the microsomal production of androstenedione-3H or dihydrotestosterone-3H. Only treatment regimes with dieldrin stimulated hepatic testosterone hydroxylases; parathion alone had no effect. This study revealed that dieldrin and parathion can interact and produce biological effects different from those caused by either pesticide alone.
Project Officer: Ronald L. Baron. Department of Pharmacology, West Virginia University Medical Center "June 1978." "EPA-600/1-78-044." PB 285 203--NTIS. "Publication resulting from this EPA Grant" (p.36-37). Includes bibliographical references (pages 31-35). Microfiche.