Record Display for the EPA National Library Catalog
RECORD NUMBER: 631 OF 834Main Title | Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets / | |||||||||||||||||||||
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Author | Boelsterli, Urs A., | |||||||||||||||||||||
Publisher | CRC Press, | |||||||||||||||||||||
Year Published | 2007 | |||||||||||||||||||||
OCLC Number | 74459862 | |||||||||||||||||||||
ISBN | 9780849372728; 0849372720 | |||||||||||||||||||||
Subjects | Molecular toxicology ; Toxicology--methods ; Molecular Biology--methods ; Signal Transduction ; Xenobiotics--pharmacokinetics ; Xenobiotics--toxicity ; Toxicologia ; Transduðcäao de sinal celular ; Biologia molecular | |||||||||||||||||||||
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Edition | 2nd ed. | |||||||||||||||||||||
Collation | 399 p. : ill. ; 25 cm. | |||||||||||||||||||||
Notes | Includes bibliographical references and index. |
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Contents Notes | Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology. |