Main Title |
Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets / |
Author |
Boelsterli, Urs A.,
|
Publisher |
Taylor & Francis, |
Year Published |
2003 |
OCLC Number |
50002578 |
ISBN |
0415284589; 9780415284585; 0415284597; 9780415284592 |
Subjects |
Molecular toxicology ;
Toxicology--methods ;
Xenobiotics--toxicity ;
Xenobiotics--pharmacokinetics ;
Signal Transduction ;
Molecular Biology ;
Toxicologie ;
Chemische stoffen ;
Biomoleculen ;
Toxicologie molculaire
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EKBM |
RA1220.3.B64 2003 |
|
Research Triangle Park Library/RTP, NC |
06/24/2005 |
EKCM |
RA1220.3.B64 2003 |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
05/21/2019 |
|
Collation |
xxiv, 314 pages : illustrations ; 25 cm |
Notes |
Includes bibliographical references and index. |
Contents Notes |
Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology. |