The present Health Effects Research Laboratory (HERL) biotechnology program is an outgrowth of previously existing programs in microbial pesticide research and genetic toxicology research. In order to meet the recommendation issued during the Coolfont Conference, HERL presently maintains this inter-divisional program which supplies support to OPP, OTS, and OSW program offices. Since Coolfont, the EPA has been given an expanded regulatory role for biotechnology organisms and products. HERL is now determining how to expand its efforts in support of biotechnology health effects research. HERL could expand its biotechnology research in other existing HERL efforts such as immunology, inhalation toxicology, developmental toxicology, and/or neurobiology. Expansions in existing biotechnology efforts are also potentially possible. For example, the Genetic Bioassay Branch has the expertise with ambient sampling to expand into biological exposure methodologies. HERL feels that any redirection and/or expansion must be done on a scientifically sound basis, that the efforts should support the short and long range needs of the program offices.