Record Display for the EPA National Library Catalog

RECORD NUMBER: 9 OF 140

OLS Field Name OLS Field Data
Main Title Alpha(2)-Adrenergic Mode of Action of Chlordimeform on Rat Visual Function.
Author Boyes, W. K. ; Moser, V. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Year Published 1988
Report Number EPA/600/J-88/039;
Stock Number PB88-225768
Additional Subjects Insecticides ; Acaricides ; Adrenergics ; Visual perception ; Central nervous system ; Laboratory animals ; Chlorine organic compounds ; Amidines ; Reprints ; Chlordimeform ; Adrenergic alpha receptors ; Toxic substances ; Visual evoked potentials ; CAS 6164-98-3 ; Formamidine/chloro-tolyl-dimethyl
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB88-225768 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 12/29/1988
Collation 17p
Abstract
The hypothesis that chlordimeform increased the amplitude of components N;P1 and P1N3 in rat pattern-reversal visual evoked potentials through actions on alpha2 adrenergic receptors was tested. Yohimbine alone had no effect on pattern-reversal evoked potential amplitude. Clonidine treatment produced a dosage related increase in amplitude of both components similar to that produced by chloroimeform. Yohimbine pretreatment attenuated the effects of subsequent treatment with either clonidine or chlordimeform. The results support the hypothesis that chlordimeform alters rat pattern-reversal evoked potentials through actions as a central nervous system alpha2 adrenergic agonist. (Copyright (c) Academic Press, Inc.)