Record Display for the EPA National Library Catalog

RECORD NUMBER: 327 OF 1617

OLS Field Name OLS Field Data
Main Title Drinking Water Criteria Document for Dinoseb.
CORP Author Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Drinking Water.
Publisher Apr 90
Year Published 1990
Stock Number PB90-215385
Additional Subjects Potable water ; Toxicology ; Water quality ; Herbicides ; Mutagens ; Carcinogens ; Reproduction(Biology) ; Lethal dosage ; Exposure ; Laboratory animals ; Mutations ; Dinoseb ; Pharmacokinetics ; Water pollution effects(Humans) ; Water pollution effects(Animals) ; Health hazards ; Carcinogenicity tests ; Path of pollutants ; Mutagenicity tests ; Oxidative phosphorylation
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-215385 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 99p
Abstract
Dinoseb, 2-sec-butyl-4,6-dinitrophenol (DNBP), is poorly soluble in water (0.52 g/L) but is readily soluble in alcohol and other organic solvents. DNBP is often used in salt form as both a pre- and postemergence herbicide for a wide variety of crops. Dinoseb has been found to be teratogenic in several species including rabbits, rats, and mice following oral, dermal, intraperitoneal, and subcutaneous administration to pregnant animals. The teratogenic effects noted in mice following intraperitoneal administration of dinoseb are diminished by its metabolism. Compounds that stimulate drug metabolism (such as phenobarbital) have been shown to decrease dinoseb toxicity. Conversely, inhibitors of drug metabolism (such as SKF-525A) potentiate dinoseb-induced teratogenicity. No calculation of excess cancer risk has been made, since only equivocal long-term effects of dinoseb carcinogenicity have been reported.