Record Display for the EPA National Library Catalog
RECORD NUMBER: 308 OF 1617
|OLS Field Name||OLS Field Data|
|Main Title||Drinking Water Criteria Document for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.|
|CORP Author||Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.|
|Additional Subjects||Potable water ; Toxicology ; Water quality ; Mutagens ; Carcinogens ; Reproduction(Biology) ; Lethal dosage ; Exposure ; Laboratory animals ; Liver ; Metabolism ; Vitamin A group ; Tetrachlorodibenzodioxin ; Pharmacokinetics ; Water pollution effects(Humans) ; Water pollution effects(Animals) ; Health hazards ; Carcinogenicity tests ; Path of pollutants ; Mutagenicity tests ; Structure-activity relationship ; Lipid peroxidation|
2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is one of the most toxic and environmentally stable tricyclic aromatic compounds belonging to chlorinated dibenzo-p-dioxins. 2,3,7,8-TCDD has been demonstrated to be teratogenic in rats, mice and rabbits, and feticidal in monkeys. The major toxic signs and terata observed were cleft palate in mice, edema, hemorrhage, and kidney anomalies in rats and extra ribs in rabbits. Some epidemiological studies have indicated a possible teratogenic effect in humans, but the evidence is not sufficient to reach a firm conclusion.