Record Display for the EPA National Library Catalog

RECORD NUMBER: 126 OF 1617

OLS Field Name OLS Field Data
Main Title Approaches to risk assessment for multiple chemical exposures /
Author Stara, J. F. ; Erdreich, L. S.
Other Authors
Author Title of a Work
Stara, J. F.
Erdreich, Linda S.
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. ;Dynamac Corp., Rockville, MD.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Year Published 1984
Report Number EPA-600/9-84-008
Stock Number PB84-182369
OCLC Number 11750664
Subjects Environmental health. ; Carcinogens. ; Chemicals.
Additional Subjects Chemical compounds ; Toxicology ; Environmental surveys ; Exposure ; Risk ; Assessments ; Mixtures ; Hazardous materials ; Mathematical models ; Industrial medicine ; Public health ; Humans ; Malignant neoplasms ; Toxic substances ; Cancer ; Occupational safety and health ; Pharmacokinetics ; Path of pollutants ; Threshold limit valves
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=20008JB3.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB84-182369 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation vii, 277 pages : illustrations ; 28 cm
Abstract
The Environmental Criteria and Assessment Office (ECAO) in Cincinnati has developed health risk assessment methods for chronic exposure to single chemical from a single route of exposure. Risk assessments for carcinogens associated an exposure level with a particular incidence of cancer using a non-threshold model which is linear at low doses. For systemic toxicants, the no-observed-adverse-effect level (NOAEL)/Uncertainty Factor approach was used to estimate an acceptable daily intake (ADI). In order to develop methods for assessing risk from exposure to mixtures of chemicals, all relevant routes and all exposure durations must be considered. The basis of the single chemical approach is constantly updated to keep pace with developments in pharmacokinetics, species and route extrapolation, mathematical models, additivity and interaction. These and other relevant issues were addressed during a 2-day workshop on 'Approaches to Risk Assessment for Multiple Chemical Exposures' held by the U.S. Environmental Protection Agency in Cincinnati, Ohio on September 29 and 30, 1982. The workshop was attended by 50 scientists from EPA and private industry. This document presents the results of this workshop, including presentations, critiques and discussion for each of the 11 subtopics covered.
Notes
"March 1984". "EPA-600/9-84-008." Includes bibliographies. Microfiche.