Record Display for the EPA National Library Catalog

RECORD NUMBER: 4 OF 6

OLS Field Name OLS Field Data
Main Title Method for Tracing Oxygen-18 In vivo: Application to Ozone Dosimetry in Animals.
Author Aissa, M. ; Hatch, G. E. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1988
Report Number EPA-68-02-4450; EPA/600/D-88/001;
Stock Number PB88-153606
Additional Subjects Ozone ; Dosimetry ; In vivo analysis ; Oxygen 18
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB88-153606 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 8p
Abstract
Data on ozone dosimetry in tissues would assist in validating models of extrapolation used in risk assessments. The paper presents some of the first measurements of ozone reaction products in mouse, rat and rabbit respiratory tissues after exposure to oxygen-18 labeled ozone (18O3). Exposure of mice, rats and rabbits to (18)O3 (1.0 ppm, 1 hr) caused enrichments as high as 15 micromoles (18)O/mole of total oxygen in the whole lung homogenates. Enrichments of 45-55 micromoles (18)O/mole were seen in alveolar macrophages and the lung surfactant pellet of rabbits.