Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Pseudopregnancy and the Decidual Cell Response (DCR) in the Rat.
Author Cummings, A. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1991
Year Published 1991
Report Number EPA/600/D-91/282;
Stock Number PB92-126895
Additional Subjects Pseudopregnancy ; Ovum implantation ; Toxic substances ; Vaginal smears ; Hormones ; Uterus ; Luteal phase ; Organ weight ; Rats ;
Library Call Number Additional Info Location Last
NTIS  PB92-126895 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 02/24/1992
Collation 14p
Pseudopregnancy, an induced physiological state in the rat which mimics the rodent's luteal phase, can be used to assess the impact of chemicals on the luteal phase of female animals. Female rats can be induced to be pseudopregnant by a variety of methods and assessment of the successful initiation and maintenance of pseudopregnancy is accomplished via vaginal cytology. The decidual cell response is a technique in which pseudopregnant rats undergo a surgical treatment of their uteri to induce uterine differentiation and proliferation. This results in massive tissue growth which mimics the response of the uterus during normal blastocyst implantation. Measurement of decidual growth during chemical treatment can be used to assess both hormonal status and uterine function. Uterine weight serves as a sensitive measure of the success of the decidual cell response.