Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Limited Epizootic of Neuroblastoma in Coho Salmon Reared in Chlorinated-Dechlorinated Water.
Author Meyers, T. R. ; Hendricks, J. D. ;
CORP Author Oregon State Univ., Corvallis.;Environmental Research Lab., Gulf Breeze, FL.
Year Published 1984
Report Number EPA-R-809344; EPA-600/J-84-003;
Stock Number PB84-175348
Additional Subjects Toxicology ; Neoplasms ; Chlorine ; Fishes ; Reprints ; Water pollution effects(Animals) ; Coho salmon ; Oncorhynchus kisutch ; Neuroblastoma
Library Call Number Additional Info Location Last
NTIS  PB84-175348 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 14p
During the 1976-77 brood year, approximately 12 cases of neuroblastoma were observed in a captive group of 100,000 fingerling coho salmon (Oncorhynchus kisutch) reared in a commercial hatchery. The tumors were large, occurring in the skeletal muscle near the dorsal fin causing conspicuous bulging of the overlying integument. Tumors examined from 3 fish each consisted of neuroblasts in trabecular patterns interspersed by glial fibrillar material and linear cavities resembling central neural canals lined by ependyma-like cells. Ganglion-like cells also were apparent morphologically and by special stain. Cancer of the tumor was characterized by an abundance of mitotic figures with occasional abnormal divisions, local invasion of normal tissues, and potentially metastatic tumor cell aggregates in organ vasculature. The etiology of this tumor may have been related to mutagenic-carcinogenic halogenated compounds possibly formed in the hatchery water supply during continuous chlorination of incoming river water.