Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Cancer Microenvironment and Therapeutic Implications Tumor Pathophysiology Mechanisms and Therapeutic Strategies / [electronic resource] :
Author Baronzio, Gianfranco.
Other Authors
Author Title of a Work
Fiorentini, Gianfranco.
Cogle, Christopher R.
Publisher Springer Netherlands,
Year Published 2009
Call Number RC261-271
ISBN 9781402095764
Subjects Medicine. ; Oncology. ; Pathology.
Internet Access
Description Access URL
Edition 1.
Collation XVI, 242 p. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Tumor Physiopathology and Microenvironment Genesis -- Inflammation and Carcinogenesis: A Change in the Metabolic Process -- Tumor Microenvironment: Aspects of Stromal-Parenchymal Interaction -- Significance of Tumor Microenvironment on the Genesis of: Interstitial Fluid, Angiogenesis, Haemostatic/Haemorheologic Abnormalities. Pathogenesis and Therapeutic Aspects -- Cancer, Stem Cells and the Neoplastic Niche -- Tumor Microenvironment, Therapeutic Perspectives and Strategies for Normalization -- Barriers to Drug Delivery in Cancer: Clinical Implications -- Hypoxia, Hyperthermia, Chemotherapy: Interactions and Opportunities -- Effects of Molecularly Targeting Hypoxia in Oncology -- Significance of the Tumour Microenvironment in Radiotherapy -- Effects of Tumor Microenvironment on Immunity and Consequent Clinical Considerations -- Effects of Tumor Microenvironment on Hyperthermia, Photodynamic and Nanotherapy -- Targeting Tumour Vascularization from Bench to Bedside: Suggestions for Combination with Hyperthermia -- New Indications for Established Drugs Able to Modify Tumour-Host Interactions. In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don't always behave the same. Understanding and eradicating cancers will require an appreciation for cancer's ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery. The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.