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RECORD NUMBER: 46 OF 349

OLS Field Name OLS Field Data
Main Title Cancer Immunology and Immunotherapy [electronic resource] /
Type EBOOK
Author Dranoff, Glenn.
Publisher Springer Berlin Heidelberg,
Year Published 2011
Call Number RC261-271
ISBN 9783642141362
Subjects Medicine. ; Oncology. ; Immunology.
Internet Access
Description Access URL
http://dx.doi.org/10.1007/978-3-642-14136-2
Collation XIV, 306 p. online resource.
Notes
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
The recent FDA approval of Provenge® as the first therapeutic cancer vaccine together with the recent demonstration that Ipilimumab®, a monoclonal antibody that blocks the negative immune checkpoint cytotoxic T lymphocyte associated antigen-4, prolongs patient survival are major achievements that usher in a new era of cancer immunotherapy. These "first-in-class" treatments reflect the substantive progress that basic and translational scientists have made towards understanding the mechanisms underlying protective tumor immunity in cancer patients Immunotherapies were first explored at the turn of the twentieth century, but the crafting of potent treatments required more detailed knowledge of how the immune system responds to cancer. Advances in genetic, cellular, and biochemical technologies have begun to yield this critical information, focusing attention on immune recognition, regulation, and escape. Indeed, the dynamic interplay of these processes in the tumor microenvironment is now recognized to play a decisive role in determining disease outcome. This volume highlights the rapid progress and breadth of research in cancer immunology, and provides a framework for anticipating many more clinical successes in cancer immunotherapy.